Once you have created a custom filter it will remain saved to the dashboard until removed. Add as many filters as necessary to achieve your ideal data view.
Here two custom filters are being applied along with the standard user and date filters.
Hover over the filter to edit the custom filters. From here, you can toggle them on and off by enabling and disabling the filters. Ultimately, you can choose to delete a filter from this view as well.
A disabled filter will look like this: